Wednesday, 29 October 2014

TF Activation Profiling Plate Arrays: Profile the Activation of up to 96 TFs

Transcription Factor (TF) Activation Profiling Arrays from Signosis are used to monitor the activities of multiple TFs simultaneously. TF Activation Profiling Plate Arrays available include:






TF Activation Profiling Plate Arrays from Signosis allow profiling of the activation of up to 96 TFs at one time, providing a tool in facilitating the analysis of transcription factors. 8 TF Activation Profiling Plates are available. 

Benefits of Transcription Factor Activation Profiling Arrays :
  • Multiplex - One assay allows the measurement of the activities for various transcription factors.
  • Quantitative comparison Differences between samples can be quantitatively compared and analysed.
  • Simple procedures - User friendly procedures similar to ELISA.
  • No special requirement - Capital instruments such as Luminex are not needed.

TF Activation Profiling Plate Array

TF activation profiling plate arrays are used for monitoring 48 different TFs including NFkB, AP1, HIF1, and p53.

List of Applicable TFs:


TF Activation Profiling Plate Array I
Product Code FA-1001

TF Activation Profiling Plate Array II – includes two 96 well plates for the comparison of two samples.
Product Code FA-1002


Stem Cell TF Activation Profiling Plate Arrays

The Stem Cell Transcription Factor Activation Plate Array allows the analysis of up to 16 stem cell-specific TFs simultaneously in mammalian samples. The assay can be used with the whole cell lysis from 1000-10, 000 cells.

List of Applicable TFs:




Stem Cell TF Activation Profiling Plate Array I 
Product Code FA-1003 


Cancer Stem Cell TF Activation Profiling Plate Array

Understanding the activation patterns of cancer stem cell related transcription factors in a tumour can help to understand the transcriptional mechanism of cancer stem cell and provide better approaches for targeting and eliminating cancer stem cells.

List of Applicable TFs:


Cancer Stem Cell TF Activation Profiling Plate Array 
Product Code FA-1004


Oxidative Stress TF Activation Profiling Plate Array

Oxidative stress occurs when the steady-state balance between pro-oxidant and anti-oxidant is changed, and oxidative stress has been reported to associate with many diseases, such as cancer, Alzheimer's disease, Parkinson's disease, atherosclerosis, and heart failure. Responses to oxidative stress are mediated by a large number of transcription factors (TFs).

List of Applicable TFs:


Oxidative Stress TF Activation Profiling Plate Array
Product Code FA-1005


ER Stress (UPR) TF Activation Profiling Plate Array

Early cellular response to ER stress includes the transcriptional up regulation of chaperone proteins, which is mediated by a large number of transcription factors (TFs).

List of Applicable TFs:


ER Stress (UPR) TF Activation Profiling Plate Array
Product Code FA-1006


Wnt/β-Catenin TF Activation Profiling Plate Array

The Wnt signaling pathway is important to both embryonic development and tumourigenesis.  β-Catenin, the central component of the pathway, functions as a cofactor for a number of transcription factors.  These transcription factors then activate transcription of Wnt target genes involved in cell proliferation, survival, and migration. Characterization of the activation of TF involved in the Wnt/ β-Catenin pathway can lead to greater understanding of various disease states and the development of treatments.

List of Applicable TFs:


Wnt/β-Catenin TF Activation Profiling Plate Array
Product Code
FA-1007


Cholesterol Metabolism TF Activation Profiling Plate Array

It has been widely reported that cholesterol homeostasis and metabolism are regulated by a group of transcription factors. Profiling the regulation and activation patterns of these associated transcription factors is crucial to further understanding and unravelling the intricate cholesterol metabolism pathway. 

List of Applicable TFs:


Cholesterol Metabolism TF Activation Profiling Plate Array
Product Code FA-1008


Caltag Medsystems is the UK distributor for Signosis. If you would like further information about TF Activation Profiling Plate Arrays or any other products from Signosis, please do not hesitate to contact us, either by email office@caltagmedsystems.co.uk or call us on 01280 827460.


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