Monday, 22 September 2014

PCSK9- Target for the Next Blockbuster Drug

Due to the medical significance of PCSK9 (Proprotein convertase subtilisin/kexin type 9) research into its interaction with the LDL receptor is growing. To keep ahead of the demand MBL have developed a number of research reagents including PCSK9 ELISA kits, an in vitro binding assay kit and numerous antibodies.

PCSK9 inhibition:
-Lowers plasma LDL-cholesterol
-Enhances the LDL-cholesterol lowering ability of statins in patients with severe hypercholesterolemia by enhancing LDL-cholesterol lowering ability of statins.

















MBL International has been leading the way in providing PCSK9 assay kits and reagents for the goal of progressing PCSK9 clinical trials.

MBL offers both the PCSK9 ELISA and the PCSK9-LDLR Bind­ing Assay – please see the table below for full product information.

Code No.
Product
Size
Price

CircuLex Human PCSK9 ELISA Kit
96 Assays
£533

CircuLex PCSK9-LDLR in vitro Binding Assay Kit
96 Assays
£540
CircuLex Mouse/Rat PCSK9 ELISA Kit
96 Assays
£492
Anti-human PCSK9
100 µg
£254
CircuLex Anti-human PCSK9 Prodomain
100 µg
£310
CircuLex Anti-human PCSK9 Prodomain
100 µg
£310
Circulex PCSK9 D374Y
10 µg
£474
CircuLex PCSK9 D374Y/δ53 in culture medium
50 µg
£237
CircuLex PCSK9 R194A (Human)
20 µg
£427
CircuLex PCSK9 Wild Type
50 µg
£427
CircuLex PCSK9 Wild Type in culture medium
50 µg
£237
Circulex PCSK9 D374Y in culture medium
50 µg
£237
Circulex PCSK9 D374Y in culture medium
50 µg
£237


Total PCSK9 Assay














The binding activity of PCSK9 and LDLR was analyzed using the CircuLex PCSK9-LDLR in vitro Binding Assay Kit. Product Code: CY-8150
As the graph shows, when PSCK9 is mutated, binding activity decreases.This kit would be ideal for looking at inhibition markers of PCSK9 activity.


Total PCSK9 Assay



Inhibitors were used to inhibit activity of PSCK9 in A431 and SW480 cells lines.  Inhibition of PCSK9 was measured using the MBL Total PCSK9 Assay, Product Code: CY-8079.

MBL is distributed exclusively in the UK by Caltag Medsystems Ltd.  View the full MBL product range here.

Contact Caltag Medsystems today to learn more about our products and how we can help you discover ways to make your science more efficient and effective: office@caltagmedsystems.co.uk

No comments:

Post a Comment

Webmaster: AnnWebCom | Site design: custardcreative.co.ukCustard Creative Copyright 2005-2015 Caltag-Medsystems Limited - all rights reserved