Thursday, 6 March 2014

Irisin: An Exercise-induced hormone secreted by skeletal muscles

Irisin has recently been described as an exercise-induced hormone secreted by skeletal muscle in mice and humans.

Irisin activates beige fat cells (these cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to Irisin), and is cleaved from the type I membrane protein FNDC5, improving systemic metabolism by increasing energy expenditure.

Circulating irisin levels have been shown to be upregulated after acute exercise and an increase of irisin under conditions of obesity may indicate a physiological function to improve glucose tolerance.

Reference: A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis: P. Boström, et al.; Nature 481, 463 (2012)

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