Thursday, 6 March 2014

FGF-1: New Function in Obesity and Metabolism

Fibroblast growth factors (FGFs) constitute a family of heparin-binding polypeptides involved in the regulation of biological responses such as growth, differentiation and angiogenesis. The biological effects of FGFs are mediated by four structurally related receptor tyrosine kinases denoted FGFR1, FGFR2, FGFR3 and FGFR4. FGF-1 is a powerful mitogen of cells of mesodermal, ectodermal and endodermal origin. FGF-1 association with heparin sulphate is a prerequisite for activation of FGF receptors.


FGF-1 plays a role in various stages of development and morphogenesis as well as in angiogenesis and wound healing processes. Recent data indicate a role of FGF-1 in inflammation and obesity. FGF-1 is selectively induced in fat cells by high-fat diet feeding and established the PPARγ-FGF-1 axis as a critical pathway that regulates adipose tissue remodelling.


Reference: Jonker, Johan W., et al. "A PPAR [ggr]-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis." Nature 485.7398 (2012): 391-394.

FGF-1 related products available from Adipogen:

FGF-1 (human) (rec.)
Product Code:
AG-40B-0137-C010                            Size: 10 µg

FGF-1 (human) (rec.) MultiPack
Product Code:
AG-40B-0137-3010                             Size: 3 x 10 µg

Adipogen provide reagents in the areas of cancer, immunology, inflammation, diabetes, & obesity, stem cells and neurodegeneration.

Caltag Medystems are the exclusive UK and Ireland distributor for Adipogen products. If you have any queries, please do not hesitate to contact us, +44 (0) 1280 827460, office@caltagmedsystems.co.uk

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