Thursday, 6 March 2014

Bim-IN Antibody - Our Current Top Selling ProSci Reagent

ProSci specialises in the production of affinity-purified peptide-specific polyclonal antibodies to novel antigens. ProSci’s current top selling antibody is Bim; a novel BH3 domain containing protein which interacts with Bcl-2 sub-family 
Immunohistochemistry of Bim
in human skin cancer cells with
Bim antibody at 20 µg/ml

Bim- IN polyclonal antibody 
      
Product Code: PSI-2065

Research area: Apoptosis                                                                   
Applications: WB, IHC
Species: Human, Mouse, Rat
Publication: PMID: 18094039 (WB
)

Bim Peptide       Product Code: PSI-2065P

ProSci’s antibodies are:
- Tested for multiple species reactivity
- Validated for multiple applications
- Widely Published
- Made in the USA
- Offered in a trial size (50 µg)

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family.

A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.

Pricing benefits for ProSci products are available to all researchers in the UK and Ireland. For details please view our ProSci Power Programme here.

If you require further information about ProSci or their products please do not hesitate to contact Caltag Medsystems by emailing office@caltagmedsystems.co.uk or call +44 (0)1280 827460.

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