Thursday, 12 July 2012

CTRP3 - Hepatic Glucose Output Regulator

CTRP3 (C1qTNF-related protein 3) plays an important role in regulating both embryonic cartilage development and postnatal longitudinal bone growth. CTRP3 stimulation leads to ERK1/2-dependent cell proliferation in human osteosarcoma cell lines. Circulating CTRP3 levels correlate inversely with circulating leptin levels in mice. Administration of sufficient recombinant CTRP3 suppressed hepatic glucose output via inhibition of gluconeogenesis and lowered blood glucose levels in both normal and ob/ob mice. Visceral adipocytes or monocytes secrete CTRP3 that antagonizes lipopolysaccharide (LPS) via a physical interaction with the TLR4/MD-2 receptor complex. These CTRP3 associated metabolically beneficial or anti-inflammatory features make CTRP3 to an interesting biomarker.

CTRP3 (human) Competitive ELISA Kit

Cross reactivity: Human

Sensitivity: 1ng/ml
Range: 0.001 to 1μg/ml
Sample Type: Cell Culture Supernatant, Plasma, Serum

Product Code: AG-45A-0042EK-KI01 (1 x 96 wells)

Product Code: AG-45A-0042TP-KI01 (2 x 96 wells)
Product Code: AG-45A-0042PP-KI01 (5 x 96 wells)

Download the datasheet here.

To view all CTRP3 related products from AdipoGen, please view this page.

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