Monday, 18 June 2012

New Supplier - Chimerigen

The collaboration between Chimerigen and AdipoGen International allows us to bring the Chimerigen product range to our UK customers.

One of Chimerigen's specialties is the production of unique immunoglobulin based chimeric fusion proteins using advanced cellular and molecular biological techniques. These reagents are used successfully in basic and applied research. 

Non-lytic Ig-based Chimeric Fusion Cytokines with Long Circulating Half-life
Unfortunately, most cytokines have short circulating half-lives. Therefore, to facilitate the study of cytokine effects in vivo, a variety of non-lytic immunoglobulin-based chimeric cytokine fusion proteins have been created, in which a cytokine sequence had been genetically fused to the hinge, CH2 and CH3 regions of an immunoglobulin.

These non-lytic fusion proteins possess both the biological functions of the cytokine moiety and a prolonged circulating half-life determined by the Fc domain. They retain the potential to direct immune cytolytic mechanisms, antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against cellular targets bound by the amino terminal binding moiety. These fusion molecules also have the promise of being minimally to negligibly immunogenic since they are made entirely from elements derived from the species to be treated.

Download the Chimerigen Product Flyer.

Popular Products
Fc Fusion Proteins
Product Code: CHI-HF-210A4
CD152 [CTLA-4] (human):Fc (human) (rec.)

Product Code: CHI-MF-110A4
CD152 [CTLA-4] (mouse):Fc (mouse) (rec.)

Product Code: CHI-HF-21002
IL-2 (human):Fc (human) (rec.)

Non-lytic Fc Fusion Proteins
Product Code: CHI-MF-120A4
CD152 [CTLA-4] (mouse):Fc (mouse) (rec.) (non-lytic)

Product Code: CHI-HF-22002
IL-2 (human):Fc (human) (rec.) (non-lytic)

Product Code: CHI-MF-12002
IL-2 (mouse):Fc (mouse) (rec.) (non-lytic)



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