Monday, 11 June 2012

Immunology

Interleukin 18 (IL-18) is an 18 kDa novel cytokine identified as a co-stimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock. IL-18 acts on T helper type 1 (Th1) cells in combination with IL-12. It strongly induces production of IFN-γ by these cells. IFN-γ is produced by activated T and NK cells and play critical roles in the defence against microbial pathogens. IFN-γ activates macrophages, enhances NK activity and B cell maturation, proliferation and Ig secretion, induces MHC class I and II antigen expression, and inhibits osteoclast activation.
Regulatory T cells (Treg) suppress overactive immune responses by inhibiting the function of activated T cells. These cells are very important for immunological tolerance of self antigens.
Natural Killer T (NKT) cells, a type of T cell that plays a significant role in immune response, produces a large quantity of INF- and IL-4 in response to glycolipids that presented by CD1d molecules. In recent years, NKT cells are reported to play a part in diabetes and tumor immunity. Therefore, a technology allowing quantitative measurement of CD1d-positive NKT cells would be a useful tool for immunology and clinical laboratory examinations.
The development of MHC Tetramer technology has provided a breakthrough in the ability to follow T cell populations defined by their antigen specificity. Tetramers have been used widely to obtain a detailed analysis of the distribution and frequency of conventional CD4+ and CD8+ antigen-specific T cells during a variety of immune responses.
Related products include:
- Human IL-18 ELISA Kit – Product Code: 7620
- Mouse IL-18 ELISA Kit – Product Code: 7625
- T-Select human CD1d Tetramer-SA-PE – Product Code: TS-HCD-1
- T-Select Mouse CD1d Tetramer-SA-PE – Product Code: TS-MCD-1
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