Tuesday, 21 February 2012

Bioss - Unconjugated and Conjugated Primary Antibodies

Bioss, has a product portfolio including over 5,500 unconjugated primary antibodies. Plus a wide range of conjugated primary antibodies for flow cytometry analysis and other applications. For every primary antibody in the Bioss portfolio, the following conjugates are available: FITC, Cy3, Cy5, Cy5.5, Cy7, PE, PE-Cy3, PE-Cy5, PE-Cy7, HRP, Biotin and Gold.

To view the Bioss portfolio and sort by conjugate, species reactivity and/or application, download the catalogue in excel format here. Tested applications include ELISA, Flow Cytometry, Western Blot, IHC & IP. Species include human, mouse, rat, chicken, dog, horse, guinea pig and more.

More than 1000 of which recognise proteins with phosphorylation, acetylation, or methylation modifications. They also offer reliable loading controls and tag antibodies.

Samples Available
Some unconjugated antibodies are also available as samples – for a full list, of samples, please click here.

Popular products include:

Mouse Anti-TNF-alpha(1F6) Monoclonal Antibody
Product Code: bsm-0387m
Tumour Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide stimulated macrophages, and causes tumour necrosis when injected into tumour bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorph nuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production.

Mouse Anti-PSA(PA5) Monoclonal Antibody
Product Code: bsm-1626m
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma.

Rabbit Anti-Caspase-8 Polyclonal Antibody
Product Code: bs-0052R
Caspases are cysteine proteases, expressed as inactive precursors that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Pro-apoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse.

For more information about Bioss please see their supplier page.


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