Runx2 - a key transcription factor associated with osteoblast differentiation

Runx2, is an essential transcription factor of skeletal tissues that is involved in the regulation of osteoblast differentiation and bone formation. Runx2-null mice have neither bone tissue nor osteoblasts. FGF receptor signaling, TGF-β, and BMP all activate transcription of Runx2, resulting in inhibition of myogenesis and myogenic differentiation.

BMP-induced Runx2 cooperates with BMP-activated Smads to induce osteogenesis. Runx2 has also been shown to play a role in the regulation of chondrocyte hypertrophy and tooth eruption.

Recent Citation: Anastasia R. Goloudina,et. Al., PNAS, Jan 2012; 109: E68 - E75.
Anti-Runx2 Monoclonal Antibody, Product Code: D130-3, 100ug, WB, IP.

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