Tuesday, 1 May 2012

CLUSTERIN - Potential Biomarker of Cancers and Type 2 Diabetes

Clusterin (Apolipoprotein J; ApoJ; SP-40,40; Sulfated glycoprotein-2; SGP-2) is a heterodimeric highly conserved disulfide-linked multifunctional glycoprotein being expressed in a wide variety of tissues and secreted in all human fluids. Clusterin is supposed to have a protective role against human atherosclerosis. In patients with type 2 diabetes mellitus serum clusterin levels are significantly higher than in healthy individuals. Furthermore, body fluids level of clusterin from patients with malignant tumors, such as breast cancer, bladder cancer and prostate cancer, are elevated. Variants of the CLU gene are associated with Alzheimer’s disease. CLU expression is increased in Alzheimer’s disease patients. In summary, clusterin likely provides a promising novel diagnostic marker in many major human diseases like diabetes, cancers or neurodegenerative diseases.

Clusterin (human) Competitive ELISA Kit

See the full range of Adipogen’s Clusterin products, including antibodies and proteins here

Caltag Medsystems is the exclusive UK distributor for Adipogen products. For further information on the Adipogen product range click here.

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