Friday, 11 May 2012

Atg16L - a Crohn's disease susceptibility gene

Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Autophagy has two ubiquitin-like conjugation systems, the Atg12 and LC3-II systems. In the Atg12 conjugation system, the Atg16L-Atg12-Atg5 forms a complex that elongate autophagic isolation membrane. After completion of the formation of the autophagosome, the Atg12-Atg5-Atg16L complex dissociates from the membrane. It has been shown that ATG16L1 is a Crohn's disease susceptibility gene.
Immunocytochemical detection of Atg16L on 4% PFA fixed nutrient normal rat kidney cell  line (NRK, left) and starved NRK (right) with PM040.

Anti-Atg16L Polyclonal Antibody, 100ug - Product Code: PM040
Anti-Atg16L Polyclonal Antibody, 10ul - sample size - Product Code: PM040B
Download the data sheet here
Suitable for use in western blot, immunoprecipitation, immunocytochemistry, immunohistochemistry and flow cytometry

Recent Citation: Kevin Moreau, et. Al., J. Cell Biol., Feb 2012; 196: 483 – 496

Caltag Medsystems is the exclusive UK distributor for MBL products. For further information on the MBL product range, please visit http://www.mblintl.com or request a copy of the MBL reference guide.

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