Friday, 11 May 2012
ACE2 - Implicated in Hypertension and Diabetes
The renin-angiotensin system (RAS) regulates system blood pressure and renal function. Angiotensin-converting enzyme 2 (ACE2) is an enzymatically active homolog of ACE, being highly specific for angiotensin cleavage. ACE2 has direct effects on cardiac functions. It is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE2 converts angiotensin I to angiotensin 1-9. ACE2 was also identified as a functional receptor for SARS coronavirus.
It has been shown that ACE2 is implicated in pathophysiological states, including myocardial ischaemia, heart failure, renal failure, atherosclerosis, and diabetes. If ACE2 is contributing to the development of hypertension is currently under investigation.
ACE2 (human) (rec.) - AG-40A-0048-C010
ACE2 (human), mAb (AC18F) – AG-20A-0032-C050
ACE2 (human), pAb – AG-25A-0042-C100
ACE2 (human) ELISA Kit – AG-45A-0022EK-KI01
ACE2 (human) (IntraCellular) ELISA Kit – AG-45A-0039EK-KI01
Adipogen products are available in the UK exclusively through Caltag Medsystems. See the full range of Adipogen’s ACE2 products, including antibodies, ELISA’s and proteins here.