Wednesday, 28 March 2012

Now Available: IGFLs & IGFLR1 - Latest Members of the TNF Superfamily

AdipoGen™ now provide IGFLs & IGFLR1 research reagents - the Newest members of the TNF Superfamily. What do we know about IGFLs & IGFLR1 so far?

1) The new insulin-growth factor-like gene family consists of four proteins in humans (hIGFL1-4) and one in mice (mIGFL).

2) mIGFL is expressed in normal skin and upregulated during inflammation.

3) hIGFL1 expression is increased in human psoriatic skin.

4) mIGFL and hIGFL1/-3 interact specifically and with high affinity to IGFLR1, a new TNFR Family Member.

5) IGFLR1 potentially exerts regulatory functions on T cell responses.

Read more about IGFL here: Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1: A.A. Lobito, et al.; J. Biol. Chem. 286, 18969 (2011).

IGFL (mouse) (rec.) Product Code: AG-40B-0091-C010 10 µg
IGFL3 (human) (rec.) Product Code: AG-40B-0090-C010 10 µg
IGFLR1 (human):Fc (human) (rec.) Product Code: AG-40B-0087-C050 50 µg
IGFLR1 (mouse):Fc (human) (rec.) Product Code: AG-40B-0085-C050 50 µg
anti-IGFLR1 (human), pAb (IN101) Product Code: AG-25B-0026-C100 100 µg

Adipogen products are available in the UK exclusively through Caltag Medsystems.

Please visit or for further product information.

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