Wednesday, 30 November 2011

ThromboStep – designed for quantitation of platelet associated immunoglobulin using flow cytometry

Generally in humans, a normal platelet count ranges from 150,000 and 450,000 per ul. Thrombocytopenia is the presence of relatively few platelets in the blood. Decreased platelet counts can be due to a number of disease processes, the quantification of platelet associated immunoglobulin is a decreased ratio in platelet production or an increase in the ratio of destruction.

Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterised by a low platelet count and mucocutaneous bleeding. The autoantibodies are directed primarily to the platelet-specific receptors CD41a (GPIIb/IIIa) and CD42b (GPIb). As a result the sensitised platelets are rapidly cleared by the monocyte-macrophage cell systems.

The determination of autoantibodies against thrombocytes allows differentiation of immune from non-immune thrombocytopenia.

The kit contains:
  • Monoclonal antibody anti CD41a PE
  • FITC polyclonal antibody to total human immunoglobulin
  • FITC polyclonal antibody to human IgA
  • FITC polyclonal antibody to human IgM
  • FITC polyclonal antibody to human IgG
  • FITC conjugated polyclonal antibody to total rabbit immunoglobulins
  • Washing Buffer
(CE Marked)

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