Friday, 21 October 2011

ECP/EDN ELISA: Eosinophil and bronchial asthma


The pathology of bronchial asthma suggests bronchial inflammation is mainly caused by leukocytes and eosinophils.
Eosinophils and leukocytes are recognized as permeating tunica mucosa bronchiorum in patients with chronic bronchial asthma in both atopic and non-atopic conditions. When stimulated, the respiratory epithelial cells induce production and release various cytokines. Cytokines such as granulocyte-macrophage colony stimulating factors (GM-CSF) retain biological activities for eosinophils; their activities can include maturity, differentiation, migration and life prolongation. Activated eosinophils secrete granular proteins that injure and exfoliate the respiratory epithelium. They also release active oxygen with the ability of injuring cells, which can constrict bronchial smooth muscle and platelet-activating factors attractive for eosinophils and neutrophils. As a result, these substances cause bronchoconstriction, hyper transmission of blood vessels and hypersecretion of mucus.

Eosinophil Cationic Protein (ECP), Eosinophil Derived Neurotoxin (EDN) and Major Basic Protein (MBP) are known to be major protein-mediators derived from activated eosinophils. Activated eosinophils play an important role in inflammatory processes especially in allergic diseases. The levels of eosinophil activation can serve as complementary data for monitoring asthma inflammation. As ECP/EDN proteins are secreted from activated eosinophils they can become markers of eosinophil activation and degranulation which can cause inflammatory disease of the airway.


  • No cross reactivity with EDN
  • For use with human serum samples
  • No cross reactivity with ECP
  • For use with human serum samples

1 comment:

  1. I'm short of words to express the goodness of God in my life. I was diagnosed of herpes simplex virus 4 years ago. Which was the worst time in my life,cos of my career and i'm just 28th. I became worried,distress,felt so rejected,dirty and pity. I started keeping in touch with many hospitals,tried many solutions,and consulted many medical practitioners to get ride of my HSV virus,none of the ativiral treatment could cure me .I started trying fruits and herbs, and with time became very interested in herbs for solutions,to get ride of my HSV. I thought my life was gonna end there, i became worried and couldn't sleep at night. That faithful Sunday morning, friend of mine crystal who visited me home came up with a good news with her HIV/ AIDS test result negative. I was shocked,but so happy to have seen that. I wouldn't believe if I haven't seen the result and that would have being my worst mistake in life. She told me it was the work of an herbalist in Africa,Dr.Abang. who prepared the HIV/AIDS cured and sent it to her husband through the DHL. I became very interest and went online to search for natural ways for my cure then I saw a testimony of a lady comments on how she was cured from cancer by the same herbalist, then,I quickly email him@
    Odeyabangherbalhome@gmail.com.its med.are very active with immune booster with no site effect.contact him for the solution to all your sickness. He cures all viruses and diseases
    Odeyabangherbalhome@gmail.com
    Is a God sent in my life....

    ReplyDelete

Webmaster: AnnWebCom | Site design: custardcreative.co.ukCustard Creative Copyright 2005-2015 Caltag-Medsystems Limited - all rights reserved