Thursday, 27 October 2011

DLL1 & DLK1 - Key Ligands of the Notch Signalling Pathway


The Notch signalling pathway is essential for cell differentiation and cell fate decisions. The components have been associated with various disorders such as cancer, leukaemia, immune disorders, developmental syndromes, stroke, cognitive symptoms and metabolic disorders.

Delta-like Protein 1 (DLL1) is essential for postnatal arteriogenesis and contributes to tumour progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Thus the measurement of soluble DLL1 in serum or plasma is like to provide a novel indication of disease status in metabolic dysfunctions.

Protein Delta homolog 1 (DLK1) is a regulator of adipocyte differentiation found in serum and urine. Levels of soluble DLK1 affect negatively or positively adipogenesis and control mesenchymal cell fate. ALK1 is frequently up regulated in myelodysplastic syndrome (MDS) patients compared to non- leukemic individuals.



DLL1 Soluble ELISA Kit (human) - Potential Biomarker for Metabolic Disorders


DLK1 Soluble ELISA Kit (human) - Potential Biomarker for
Metabolic Disorders
Product Code: AG-45A-0032

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