Tuesday, 18 October 2011

Diabetes, Obesity and Metabolism ELISA's from Symansis

Symansis have a new range of ELISA kits for research within the areas of diabetes, obesity and metabolism. These include insulin, fatty acid binding protein and FGF-21 ELISA arrays.

Fatty Acid Binding Protein 4/aP2 Human ELISA Array
Product code: EFABP4SY

Fatty-acid binding protein 4 (FABP4), also termed adipocyte fatty-acid binding protein (A-FABP), or aP2, is a novel adipocyte-expressed factor which accounted for ~6% of total cellular proteins. Several animal experiments suggested that FABP-4 plays a key role in the link between obesity and various features of metabolic syndrome. Mice with targeted disruption of FABP-4 accompany FABP-5 almost completely protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and fatty liver disease. Studies in humans found FABP-4 serum levels were significantly increased in overweight and obese subjects, which predicted the risk to develop a metabolic syndrome and type 2 diabetes. Additionally, serum FABP-4 levels were associated with nonalcoholic fatty liver disease, carotid atherosclerosis and coronary artery disease.

FGF-21 ELISA Arrays

Fibroblast growth factor 21 (FGF-21) is a novel protein that has been implicated in the regulation of lipid and glucose metabolism under fasting and ketotic conditions. In murine models, FGF-21 is predominantly expressed in liver, but it also expressed in adipose tissue and pancreatic ß-cells. FGF-21 stimulates glucose uptake in adipocytes. It also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. Furthermore, elevated plasma FGF-21 concentrations in humans appear to be related to the presence of hepatic and peripheral insulin resistance.

Download the datasheet here – Human & Mouse/Rat

Insulin ELISA Arrays

Ultra Sensitive Insulin Kits
Product code: EUSRISY (rat)
Product code: EUSMISY (mouse)

These kits are designed for the quantitative determination of insulin in rat/mouse serum and plasma in lean/healthy rats and mice as the level of insulin is extremely low. The ultra-sensitive kit is too sensitive to be used for obese/hit fat rat model systems.

High Sensitive Insulin Kits
Product code: EHSRISY (rat)
Product code: EHSMISY (mouse)

Kits are designed for the quantitative determination of insulin in rat/mouse serum and plasma from high fat diet-induced obese rat/mouse model systems.

Wide Range Insulin Kits
Product code: EWRRISY (rat)
Product code: EWRMISY (mouse)

For the quantitative determination of insulin in rat or mouse serum, plasma and fluid over a wide range from 1 ng/ml to 50 ng/ml. These kits are excellent for drug screening experiments or initial screening experiments where insulin levels are not known.

Download the datasheet here – Rat & Mouse

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