Friday, 7 October 2011

BAFF – A Key Factor in Autoimmune Diseases

BAFF (B-cell activating factor; BLyS; B lymphocyte stimulator; TNFSF13B; TALL-1; CD257), belonging to the TNF family, is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune

For a quantitative and specific measurement of BAFF levels diseases, such as Sjogren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukaemia (B-CCL).
  • The first “highly sensitive” mAb/mAb-based human BAFF immunoassay
  • Detects BAFF levels in in patients with healthy and pathological conditions
  • Secured re-supply – available from stock
  • Inter- and intra- batch reproducibility
  • Small original sample amounts – only 5ul needed
  • Works on serum, plasma and cell culture supernatant
BAFF ELISA Kit (Human) – Hypersensitive
Product Code: AG-45B-0001-KI01 (1 x 96 well plate)

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