Monday, 10 October 2011

Abnova – Polyethylene Glycol Matched Antibody Pair

This matched antibody pair set binds to the repeating subunits of the polyethylene glycol polymer and can be employed to detect and quantify PEGylated compounds.
Polyethylene Glycol (PEG) is a long chain polymer that has been approved by the Food and Drug Administration for human intravenous, oral and dermal applications. Covalent attachment of PEG (PEGylation) to proteins can reduce their immunogenicity, minimize proteolytic cleavage and increase their serum half-life. PEG has also been attached to small molecules and liposomes for more selective delivery. PEG-modification of superparamagnetic iron oxide and quantum dots can improve their biocompatibility and reduce non-specific uptake.

Characteristics of PEG

  • Water soluble, nontoxic, biocompatible
  • Covalently conjugated to proteins, small molecules, and particles
  • Decreased immunogenicity
  • Minimized proteolytic cleavage
  • Increased bioavailability
PEG Matched Antibody Pair
  • Capture antibody: mouse monoclonal anti-PEG, IgM
  • Detection antibody: mouse monoclonal anti-PEG, IgG1
  • Immunoblot
  • Immunoprecipitation
  • Sandwich ELISA
  • Flow Cytometry
Product Code: AP0001

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