Friday, 23 September 2011

Interleukin-33


Interleukin-33, a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The predicted 270-amino acid human pro-IL-33 has a calculated molecular mass of 30 kDa. Whether pro-IL-33 needs to be cleaved to be active and whether caspase-1 is required is still a matter of controversy. However, it has been reported that IL-33 is biologically active in a caspase-1 independent manner. The heterodimeric IL-33 receptor complex consists of ST2 and IL-1 receptor accessory protein (IL-1rAp) and mediates signaling through the TLR domain of IL-1rAp.



Binding of IL-33 to its receptor results in the recruitment of myD88, IRAK1, and IRAK4 to the receptor complex, activating NF-κb, Iκbα and numerous MAPKs. Cell-specific variations in the IL-33 induced signaling pathway have been described, such as the requirement of TRAF6 for IRAK recruitment in fibroblasts. In addition, IL-33 may function as a transcriptional repressor mediated by the N-terminal homeobox domain. Soluble ST2 can bind IL-33 directly and acts as a decoy receptor. Taken together IL-33 may be a dual function cytokine with both extracellular and intracellular signalling, a property it shares with IL-1α.

IL-33 affects the various cell types that express membrane ST2. ST2 is selectively expressed by TH2 but not TH1 cells. IL-33 is described as a modulator of inflammation, mediating TH2 immune responses. Administration of purified IL-33 in vitro and in vivo induces TH2-associated cytokines such as IL-5 and IL-13 and reduces production of IFN-γ from TH1 cells. IL-33 is a potent inducer of pro-inflammatory cytokines and chemokines.

The ability of IL-33 to target numerous immune cell types, like TH2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of wide range of diseases such as:
  • Arthritis
  • Asthma
  • Atopic Allergy and Anaphylaxis
  • Cardiovascular Diseases / Atherosclerosis
  • Nervous System Diseases
  • Sepsis

2 comments:

  1. I'm short of words to express the goodness of God in my life. I was diagnosed of herpes simplex virus 4 years ago. Which was the worst time in my life,cos of my career and i'm just 28th. I became worried,distress,felt so rejected,dirty and pity. I started keeping in touch with many hospitals,tried many solutions,and consulted many medical practitioners to get ride of my HSV virus,none of the ativiral treatment could cure me .I started trying fruits and herbs, and with time became very interested in herbs for solutions,to get ride of my HSV. I thought my life was gonna end there, i became worried and couldn't sleep at night. That faithful Sunday morning, friend of mine crystal who visited me home came up with a good news with her HIV/ AIDS test result negative. I was shocked,but so happy to have seen that. I wouldn't believe if I haven't seen the result and that would have being my worst mistake in life. She told me it was the work of an herbalist in Africa,Dr.Abang. who prepared the HIV/AIDS cured and sent it to her husband through the DHL. I became very interest and went online to search for natural ways for my cure then I saw a testimony of a lady comments on how she was cured from cancer by the same herbalist, then,I quickly email him@
    Odeyabangherbalhome@gmail.com.its med.are very active with immune booster with no site effect.contact him for the solution to all your sickness. He cures all viruses and diseases
    Odeyabangherbalhome@gmail.com
    Is a God sent in my life....

    ReplyDelete
  2. I'm short of words to express the goodness of God in my life. I was diagnosed of herpes simplex virus 4 years ago. Which was the worst time in my life,cos of my career and i'm just 28th. I became worried,distress,felt so rejected,dirty and pity. I started keeping in touch with many hospitals,tried many solutions,and consulted many medical practitioners to get ride of my HSV virus,none of the ativiral treatment could cure me .I started trying fruits and herbs, and with time became very interested in herbs for solutions,to get ride of my HSV. I thought my life was gonna end there, i became worried and couldn't sleep at night. That faithful Sunday morning, friend of mine crystal who visited me home came up with a good news with her HIV/ AIDS test result negative. I was shocked,but so happy to have seen that. I wouldn't believe if I haven't seen the result and that would have being my worst mistake in life. She told me it was the work of an herbalist in Africa,Dr.Abang. who prepared the HIV/AIDS cured and sent it to her husband through the DHL. I became very interest and went online to search for natural ways for my cure then I saw a testimony of a lady comments on how she was cured from cancer by the same herbalist, then,I quickly email him@
    Odeyabangherbalhome@gmail.com.its med.are very active with immune booster with no site effect.contact him for the solution to all your sickness. He cures all viruses and diseases
    Odeyabangherbalhome@gmail.com
    Is a God sent in my life....

    ReplyDelete

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